Forty years’ experience as a bacterial geneticist has taught me that bacteria possess many cognitive, computational and evolutionary capabilities unimaginable in the first six decades of the twentieth century. Analysis of cellular processes such as metabolism, regulation of protein synthesis, and DNA repair established that bacteria continually monitor their external and internal environments and compute functional outputs based on information provided by their sensory apparatus. Studies of genetic recombination, lysogeny, antibiotic resistance and my own work on transposable elements revealed multiple (...) widespread bacterial systems for mobilizing and engineering DNA molecules. Examination of colony development and organization led me to appreciate how extensive multicellular collaboration is among the majority of bacterial species. Contemporary research in many laboratories on cell–cell signaling, symbiosis and pathogenesis show that bacteria utilise sophisticated mechanisms for intercellular communication and even have the ability to commandeer the basic cell biology of ‘higher’ plants and animals to meet their own needs. This remarkable series of observations requires us to revise basic ideas about biological information processing and recognise that even the smallest cells are sentient beings. (shrink)

This article provides an overview of the origins and development of green chemistry. Aiming to contribute to the understanding of green chemistry, basically from a historical point of view, this overview argues that contextual influences and the user friendliness of the term are drivers for the explosive growth of green chemistry. It is observed that political support for its development has been significant, in which the Pollution Prevention Act of 1990 was a formal political starting-point, but informally the origins of (...) green chemistry go back to before 1990. US EPA played an important role in all this, but did not solely contribute to the growth of green chemistry. (shrink)

In the Spring of 1944, an informal discussion took place in Cambridge between Mr. R. S. Whipple, Professor Allan Ferguson and Mr. F. H. C. Butler, concerning the formation of a national Society for the History of Science. This is the opening sentence of the inaugural issue of the Bulletin of the British Society for the History of Science, the Society's first official publication. Butler himself was the author of this outline account of the subsequent approach to the Royal Society, (...) the parallel moves to establish a National Committee of the International Academy of the History of Science, the formation of a provisional committee to prepare a draft constitution for a national society, and the proceedings of the first Annual General Meeting in May 1947. Whipple had been in Cambridge to discuss his offer to present his collection of old scientific instruments to the University and the possible foundation of a new museum, and Butler, as Secretary of the History of Science Committee in Cambridge, was the chief mover in both this development and an initiative coupled with it to establish a department of the history of science. (shrink)

This book examines the concept of public interest against the background of English politics from the Civil War to the coming of the Hanoverians. These years witnessed both the rise of the modern notion of the public interest as a part of ordinary political language and the growth of a social philosophy of individualism. The new ideas challenged the _status quo_, based on order, reason of state and national power, in the name of legitimate self-interest and respect for the rights (...) of the private person. In presenting a complex set of ideas in their historical context, the author examines both abstract philosophies and the issues of the day as recorded in press, pulpit and law courts. A chapter devoted to economic thought includes a re-assessment of the social assumptions of mercantilism. (shrink)

What role, if any, should emotions play in clinical reasoning and decision making? Traditionally, emotions have been excluded from clinical reasoning and decision making, but with recent advances in cognitive neuropsychology they are now considered an important component of them. Today, cognition is thought to be a set of complex processes relying on multiple types of intelligences. The role of mathematical logic or verbal linguistic intelligence in cognition, for example, is well documented and accepted; however, the role of emotional intelligence (...) has received less attention—especially because its nature and function are not well understood. In this paper, I argue for the inclusion of emotions in clinical reasoning and decision making. To that end, developments in contemporary cognitive neuropsychology are initially examined and analyzed, followed by a review of the medical literature discussing the role of emotions in clinical practice. Next, a published clinical case is reconstructed and used to illustrate the recognition and regulation of emotions played during a series of clinical consultations, which resulted in a positive medical outcome. The paper’s main thesis is that emotions, particularly in terms of emotional intelligence as a practical form of intelligence, afford clinical practitioners a robust cognitive resource for providing quality medical care. (shrink)

The classical Feferman–Vaught Theorem for First Order Logic explains how to compute the truth value of a first order sentence in a generalized product of first order structures by reducing this computation to the computation of truth values of other first order sentences in the factors and evaluation of a monadic second order sentence in the index structure. This technique was later extended by Läuchli, Shelah and Gurevich to monadic second order logic. The technique has wide applications in decidability and (...) definability theory. Here we give a unified presentation, including some new results, of how to use the Feferman–Vaught Theorem, and some new variations thereof, algorithmically in the case of Monadic Second Order Logic MSOL . We then extend the technique to graph polynomials where the range of the summation of the monomials is definable in MSOL . Here the Feferman–Vaught Theorem for these polynomials generalizes well known splitting theorems for graph polynomials. Again, these can be used algorithmically. Finally, we discuss extensions of MSOL for which the Feferman–Vaught Theorem holds as well. (shrink)

In arbitrating between representational and relational theories of perception, perceptual illusions—cases in which a subject’s perceptual experience diverges from the way the world really is—constitute an important battleground. The debate has, however, been dominated by discussions of visual perception. In attempting to extend the debate to audition, it is appropriate to start by considering what is thought to be a key case of auditory illusion. I consider the phenomenon of the ‘missing fundamental’, as well as examining a notion that is (...) often deployed by representationalists to explain it—namely, perceptual inference. Though it is frequently deployed as an explanatory concept by inferentialists, the notion of perceptual inference is somewhat opaque. Here, I formulate a ‘job description’ for perceptual inference, involving rule-following. I then identify two sets of cases that commonly prompt the invocation of perceptual inference: namely, cases of perceptual illusion, and cases of veridical perception where the perceptual content outstrips the information present in the stimulus. I then argue that an appeal to perceptual inference is unnecessary, in the case of the missing fundamental, for two reasons. Firstly, the missing fundamental is not, after all, a clear candidate for the ascription of inferential capacity to the auditory system: it is neither an illusion, nor is it the case that the stimulus is crucially impoverished. That is, it submits to a ‘direct’ explanation. Secondly, given the adequacy of a simpler explanation, and the difficulty between distinguishing between real rule-following and the mere appearance of it, I argue that we should avoid ascribing inferential capacity to the auditory system. I close by considering objections, and offering replies. (shrink)

We investigate the expressive power of second-order logic over finite structures, when two limitations are imposed. Let SAA ) be the set of second-order formulas such that the arity of the relation variables is bounded by k and the number of alternations of second-order quantification is bounded by n . We show that this imposes a proper hierarchy on second-order logic, i.e. for every k , n there are problems not definable in AA but definable in AA for some c (...) 1 , d 1 . The method to show this is to introduce the set AUTOSAT of formulas in F which satisfy themselves. We study the complexity of this set for various fragments of second-order loeic. For first-order logic FOL with unbounded alternation of quantifiers AUTOSAT is PSpace complete. For first-order logic FOL n with alternation of quantifiers bounded by n , AUTOSAT is definable in AA . AUTOSAT) is definable in AA for some c 1 , d 1. (shrink)

Tertium datur - on the conception of truth in Dutch 'Ethical Theology'In this article the 'third option' on the Dutch theological scene of a century ago is examined. The 'Ethical Theology', as this option is known, is explained on the basis of its characteristic conception of truth as something that cannot be encapsulated in propositions but which can be encountered. In this context the relationship between the Ethicals and their rivals on both the left and the right is discussed. In (...) conclusion, an evaluation is given of the achievement of the Ethical current and its accommodation of reason and faith in a single theory. (shrink)

As Astronomer Royal from 1835 till 1881, G. B. Airy had a very important influence on nineteenth-century British astronomy. His personal qualities combined with his office to give him a position of great authority within the astronomical and general scientific communities, and his powers of organization and work on instrumentation transformed the Royal Observatory. A feature of Airy's work was an extensive interest in horology—particularly in astronomical regulators, marine chronometers and driving clocks for chronographs and equatorial telescopes. He was also (...) concerned with building important turret clocks, and he established a public time service based at Greenwich. The enormous quantity of surviving material makes a complete review of Airy's career a daunting prospect; but the horology is a microcosm, where we can study on a manageable scale his attitudes to the Observatory, to its relation to society, and to the role of the Astronomer Royal as a public servant. (shrink)

Isaac Newton's closest approach to a system of the world in the critical period 1681–84 is provided in a set of untitled propositions concerning comets. They drastically revise his position maintained against Flamsteed in 1681 and may signal his adoption of a single comet solution for the appearances of 1680/1. Points of agreement and difference with the key pre-Principia texts of 1684–85 are analysed. He shows substantial control of the phenomena of tails which change very little in mechanical detail throughout (...) his subsequent work. An emerging theory of gravitation brings planets, their satellites, and comets under the same laws of motion, yet retains a celestial vortex and includes a singular proposition in lieu of the usual formulation of Keplers area law. The analysis raises questions on a number of issues of recent Newtonian scholarship ranging from his achievement following his correspondence with Robert Hooke in 1679 to his veneration of the wisdom of the ancients. (shrink)

Current critical pedagogical scholarship has theorized the epistemological and social intersection between globalization and educational technology according to two distinct positions. For some, this intersection offers new liberatory knowledges and opportunities that can subvert social homogenization and economic disparity. For others, this relationship is just another phase of neoimperialism that should be politically and ideologically resisted. In contrast, we argue that the intersection between globalization and educational technologies is rather a manifestation of larger economic and logical forces, and that resistance (...) to such circumstances can neither be purely ideological or social. Instead, we contend that such a theoretical and pedagogical foreclosure dialectically actualizes conditions for real change—particularly when it complicates educational research technologies and their impact on epistemological multiplicity. (shrink)

We examine “de Broglie-Bohm” causal trajectories for the two electrons in a nonrelativistic helium atom, taking into account the spin-dependent momentum terms that arise from the Pauli current. Given that this many-body problem is not exactly solvable, we examine approximations to various helium eigenstates provided by a low-dimensional basis comprised of tensor products of one-particle hydrogenic eigenstates.First to be considered are the simplest approximations to the ground and first-excited electronic states found in every introductory quantum mechanics textbook. For example, the (...) trajectories associated with the simple 1s(1)1s(2) approximation to the ground state are, to say the least, nontrivial and nonclassical.We then examine higher-dimensional approximations, i.e., eigenstates Ψ α of the Hamiltonian in this truncated basis, and show that ∇ i S α =0 for both particles, implying that only the spin-dependent momentum term contributes to electronic motion. This result is independent of the size of the truncated basis set, implying that the qualitative features of the trajectories will be the same, regardless of the accuracy of the eigenfunction approximation.The electronic motion associated with these eigenstates is quite specialized due to the condition that the spins of the two electrons comprise a two-spin eigenfunction of the total spin operator. The electrons either (i) remain stationary or (ii) execute circular orbits around the z-axis with constant velocity. (shrink)

La parole est l'entre-deux qui sépare et unit moi et le monde, moi et toi, moi et moi-même. On se demande quelle est la relation entre moi et ma parole, si la parole découle de l'essence même de mon être. Une analyse phénoménologique, qui partirait du dialogue comme d'un donné indubitable, ne suffit pas tout à fait, puisqu'il il s'agit d'un sens éventuel du dialogue pour le tout de mon être. Il faut donc aborder la question d'un point de vue (...) d'où le dialogue lui-même est mis en suspens. Commençons par l'indubitable absolu : l'être. Il y a quelque chose, quoi que ce soit, il y a au moins la question même de l'être. Mais cette question qui se met elle-même en question, se sait être. Et qu'est cela sinon moi-même, pas encore opposé, il est vrai, à toi, à lui, à nous ? Pourtant je ne suis pas l'être ; il y a en moi une dualité entre essence et être, et une dualité entre être et penser. Je sais que je suis, je cherche encore qui je suis. Eh bien, je suis « ici et maintenant » , c. à. d. je suis dans un ordre spatio-temporel, par mon corps, qui est donc ce qui m'exprime à moi-même, ma parole. Mais mon corps est originellement en commerce avec les êtres du monde, et j'ai le sentiment de cette situation par la perception et le comportement. En révélant le sens des êtres du monde, en leur donnant des noms de mon point de vue, je me nomme moi-même. En revenant sur la voie parcourue jusqu'ici, l'article démontre que ce n'est pas seulement mon monde que je nomme. Le « moi » de la certitude absolue est un « nous » pas encore détaillé. Et à l'intérieur de ce « nous » jaillit, par ta foi en moi, l'opposition communicative entre moi et toi, que j'expérimente surtout dans la corrélation de la voix et de l'ouïe. La parole fonde la communauté, puisqu'en exprimant mon être elle s'adresse à vous, et manifeste ainsi mon être comme « être-avec » . L'être même est infini, et donc communicabilité pure, et donc parole. Mais notre parole humaine n'est que participation déficiente de la communication immédiate qui serait l'identité de l'être, le connaître et l'aimer. Elle reste moyen, et donc succédané de l'immédiat, et donc ambigue. Notre dialogue doit se transcender dans l'inexprimable, dans le silence. La parole essentielle, la parole de l'amour, est pour les hommes la parole la plus dangereuse et la plus incertaine. Elle ne se prouve que par la fidélité. Mais tout ce que nous disons et faisons est destiné à devenir l'incarnation de cette parole. (shrink)

August Wilhelm von Schlegel, who did so much to rend the already torn artistic reputation of Euripides in the early nineteenth century, is singularly lenient in his criticism of the Hecuba. His adverse comment is limited to three points only: The first, that ‘the two actions of this piece—the sacrifice of Polyxena and the revenge on Polymestor on account of the murder of Polydorus—have nothing in common with each other but their connexion with Hecuba’; the second, that ‘the second half (...) destroys the soft impressions of the first in a highly repulsive manner’; and the third, that it is ‘not very suitable that Hecuba should display such presence of mind in her revenge.’ In this leniency he differs from one of the latest modern English critics, Professor G. Norwood,2 who does not hesitate to condemn the play as ‘on the whole poor and uninteresting,’ ‘far below the best of Euripides' work’; and from his great predecessor, J. J. Reiske, who condemned the play on ten distinct counts, all different from those that form the basis of SchlegeFs own argument. (shrink)

We study the effects of Vopěnka's principle on properties of model theoretic logics. We show that Vopěnka's principle is equivalent to the assumption that every finitely generated logic has a compact cardinal. We show also that it is equivalent to the assumption that every such logic has a global Hanf number.

We define and study the class of all stack algebras as the class of all minimal algebras in a variety defined by an infinite recursively enumerable set of equations. Among a number of results, we show that the initial model of the variety is computable, that its equational theory is decidable, but that its equational deduction problem is undecidable. We show that it cannot be finitely axiomatised by equations, but it can be finitely axiomatised by equations with a hidden sort (...) and functions. This class of all stack algebras, together with its specifications, can be used to survey the many models in the literature on stacks in a systematic way, and hence give the study of the stack some mathematical coherence. Article Outline. (shrink)

In the past few years considerable attention has been given to a relatively new method of prenatal diagnosis known as chorionic villus sampling (CVS). Because CVS can be performed in the first trimester it is hailed by many as a significant advance over amniocentesis. What has not been as publicized, however, are the disadvantages of CVS and earlier prenatal diagnosis. The emotional costs of CVS in terms of the greater number of both spontaneous and selective abortions following CVS, the use (...) of CVS for sex selection and, because of the greater social acceptability of first trimester abortion, the possibility of increased pressure on women to undergo prenatal diagnosis by health insurance companies, medical professionals and government agencies, all need to be weighed against the advantages of early prenatal diagnosis. (shrink)